Assessment of linezolid efficacy and safety in MDR- and XDR-TB: an Indian perspective.

نویسندگان

  • Z F Udwadia
  • T Sen
  • G Moharil
چکیده

C.T. Bolliger*, A. Brunelli and A. Charloux *Internal Medicine, University of Stellenbosch, Faculty of Health Sciences, Cape Town, South Africa, Dept of Thoracic Surgery, Umberto I Regional Hospital, Ancona, Italy, and Physiologie et Explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Correspondence: C.T. Bolliger, Internal Medicine, University of Stellenbosch, Faculty of Health Sciences; 7505 Tygerberg, Cape Town, South Africa, 75505. E-mail: [email protected]

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis.

Linezolid is used to treat patients with multidrug-resistant (MDR)/extensively drug-resistant (XDR)-tuberculosis (TB) cases, although clinical data on its safety, tolerability and efficacy are lacking. We performed a retrospective, nonrandomised, unblinded observational study evaluating the safety and tolerability of linezolid at 600 mg q.d. or b.i.d. in MDR/XDR-TB treatment in four European co...

متن کامل

Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients.

OBJECTIVES Linezolid may be an effective treatment for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). The objective was to evaluate the efficacy, tolerability and adverse events of a 300 mg daily dose of linezolid in the treatment of MDR/XDR-TB. PATIENTS AND METHODS We retrospectively reviewed the medical records of 51 MDR-TB patients, including 26 patients ...

متن کامل

Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB.

Clinical experience on meropenem-clavulanate to treat tuberculosis (TB) is anecdotal (according to case reports on 10 patients). The aim of our case-control study was to evaluate the contribution of meropenem-clavulanate when added to linezolid-containing regimens in terms of efficacy and safety/tolerability in treating multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB cases aft...

متن کامل

Linezolid: an effective, safe and cheap drug for patients failing multidrug-resistant tuberculosis treatment in India.

Linezolid is identified as an effective drug with which to treat patients failing multidrug-resistant (MDR)-tuberculosis (TB) treatment. However, cost and safety are the concerns. In India, the average price of a 600-mg pill of linezolid is less than one US dollar, much cheaper than most of the third-line drugs. A prospective study of 29 MDR-TB treatment failure patients (16 with laboratory-pro...

متن کامل

Linezolid for multidrug-resistant tuberculosis: How should we approach it?

Multidrug-resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, poses a major threat to public health and TB control worldwide. According to the World Health Organization (WHO), MDR-TB accounted for 480,000 new cases of TB in 2013, of which 9% were extensively drug-resistant TB (XDR-TB), defined as MDR-TB with resistance to a fluoroquinolone and at least o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The European respiratory journal

دوره 35 4  شماره 

صفحات  -

تاریخ انتشار 2010